Immunotherapy in breast cancer

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Added: 04.02.2021
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Karen Peterson was no stranger to cancer. When she learned that her breast cancer had returned and was now stage 4, she took to the internet to find treatment that might save her life. Instead, I was empowered. When I was three years old, I said to my mom, my tummy hurts. Prior to my birth, my brother passed away at two months old from the cancer.
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Immunotherapy for Breast Cancer

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Side Effects of Immunotherapy - National Cancer Institute

The idea of using the immune system to fight cancer is over years old. A new molecular approach led to a better understanding of the immune system. Checkpoint regulation, understanding the roles of Tregs, Th1, and Th2, development of Chimeric antigen receptor CAR -T cells, as well as regulation of dendritic cells and macrophages, are just a few examples of our understating that has also led to the discovery of immune checkpoint inhibitors ICIs and modulators. This led the Nobel Prize committee in , to award Dr. James P. Allison the Nobel Prize in medicine for the discovery of Cytotoxic T-lymphocyte-associated antigen-4, and Dr.
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Immunotherapy can cause side effects, many of which happen when the immune system that has been revved-up to act against the cancer also acts against healthy cells and tissues in the body. Different people have different side effects. The ones you have and how they make you feel will depend on how healthy you are before treatment, your type of cancer, how advanced it is, the type of immunotherapy you are getting, and the dose. You might be on immunotherapy for a long time, and side effects can occur at any point during and after treatment. Doctors and nurses cannot know for certain when or if side effects will occur or how serious they will be.
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Researchers from the Los Angeles-based Terasaki Institute for Biomedical Innovation TIBI say they have successfully designed a method for rapid testing large numbers of potential immunotherapy drugs against live tumor cells for accurate and easily analyzable data. They began by culturing spherical aggregates of breast cancer cells in a custom-fabricated, 3D printed, transparent chip with conical microwells, which were designed for optimum growth and stability of the cellular spheres. This system facilitates facile monitoring of T-cell inhibition and reactivation using metrics such as tumor infiltration and interleukin-2 IL-2 secretion. The iHOC is a platform that can be used to model and monitor cancer-immune interactions in response to immunotherapy in a high-throughput manner. And its design allows for high-volume testing, which lends itself well to the rapid screening of immunotherapeutic drugs.
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